Share Email Opening Title Investigator I, mRNA Development  EOE Statement We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status or any other characteristic protected by law.   Description The Investigator will: Develop and execute experimental bench work to build up neoantigen vaccine and therapeutic mRNA platform Design and execute neoantigen peptide identification and production Design and optimize DNA constructs for in vitro mRNA production, candidate screening and lead selection Design and conduct in vitro and in vivo pharmacology, safety and efficacy studies Collaborate with internal and external collaborators Performing data analyses and delivering data presentation to the scientific team Ensuring maintenance of industry-quality records to provide documentation Contribute to high impact research publications/patent applications and regulatory filings Qualifications PhD (+ 5 years) experience in mRNA chemistry/biology; nanomedicine; nucleic acid pharmacology; synthetic nucleic-acid-based vaccines, immunotherapy, oncology or related discipline Deep knowledge in mRNA biology and clinical applications of mRNA therapy Deep knowledge in tumor biology, immunotherapy, and neoantigen vaccinology Hands-on experience in neo-antigen identification and production Hands-on experience with various molecular biology techniques, including DNA/RNA operations, in vitro transcription for mRNA synthesis, quantitative PCR, RT-qPCR, branched DNA assay, ddPCR, expression vector design, NGS, shRNA and miRNA Hands-on experience in mammalian cell cultures, cell-based assays and immunological assays for drug research and development Familiar with and willing to work with rodent tumor models Outstanding problem-solving and troubleshooting skills Must be self-motivated, detail-oriented, organized Must be capable of working independently as well as in a collaborative/group environment Good communication and interpersonal skills Ability to multi-task in a fast-paced work environment Strong commitment to accountability with can-do attitude for completion of projects in accordance with team plans and timelines   Position Requirements Education – PhD in immunology/biology Experience – at least 3-5 years post PhD in immunology/vaccine development, preferably in an industry is desirable. The candidate must have experience in vaccine research and development, preferably in infectious disease or oncology therapeutic vaccines area. Within HPV therapeutic vaccine research experience is highly desirable. Must have strong immunology background with hands on in vitro and in vivo experimental experience. In vivo experience with both rodent and non-human primate studies is desirable. Should be able to carry out research independently, generate high quality experimental data inhouse (in vitro and ex-vivo) and at CROs (in vivo), analyze and interpret data, present to upper management and at scientific conferences. Must have experience working with mRNA delivery formulations. Should have ability to move projects forward and produce data in time leading to IND filings. Experience working with CROs for running rodent and NHP in vivo studies is required. Must familiar with a broad range of bioanalytical, molecular biological and/or biochemical assays to characterize mRNA and its impact on disease progression (such as ELISA, MSD, Flow Cytometry, RT-PCR, Nanostring, bioanalyzer, etc.) An individual with mRNA vaccines experience is highly desirable. Must have excellent verbal, written and interpersonal communication skills. Evidence of strong publications record and conference presentations in the area of specialty is required.   Location Woburn, MA   About the Organization   This position is currently not accepting applications. To search for an open position, please go to http://LuyePharmaLTD.appone.com WE ALSO RECOMMEND Other Jobs Within Same Category -- None found -- Other Jobs Within 60 Miles -- None found --

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