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Title

Intern: Clinical Immunology and Bioanalysis Proteomics/Metabolomics  

EOE StatementWe are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status or any other characteristic protected by law.
 
About the Organization AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit www.astrazeneca.com.



 
Description

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of small molecule and biologic prescription medicines. AstraZeneca is pioneering innovative research and exploring novel pathways across key therapeutic areas, including respiratory, inflammation and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines.

We are currently seeking candidates who are working towards obtaining a graduate (M.S, PhD, MD/PhD, PharmD) degree in Chemistry, Biochemistry or Pharmaceutical Sciences for an internship during 2020 in the DMPK department supporting clinical and pre-clinical PK/PD, biomarker (proteomics and metabolomics) studies.

Potential intern projects:

Applications of high-resolution accurate mass (HRAM) spectrometry to:

intact mass and proteomic analysis characterization of in vivo biotransformation of biologics

proteomics/metabolomics/lipidomics biomarker studies

The intern will have the opportunity to learn and utilize state-of-the-art HRAM spectrometry instruments with the goal to discover and validate clinically-relevant biomarkers or understand in vivo biotransformation of biotherapeutics. The intern is expected to perform specific experiments with minor supervision following hands-on training. Assay design and preparation for most assays will be conducted with supervision. Data analysis and interpretation will be conducted with supervision. At the end of the internship the intern is expected to give an oral presentation about their research.

 
Position Requirements

Position Requirements:

  • Essential Requirements:

    Bachelor’s degree or equivalent in Chemistry, Biochemistry or Pharmaceutical Sciences

    Strong background in analytical biochemistry/chemistry with emphasis on LC-MS/MS

    Expertise in MS-based proteomics or metabolomics

    Hands-on experience with chromatographic separation of complex analytes by LC; high resolution mass spectrometers, protein digestion/metabolite extraction sample preparation

    Proficiency with mass spectrometry data acquisition and database searching software, as well as spreadsheet, word processing, and graphical computer programs

    Good organizational, documentation and technical writing skills

    Good command of English (written and oral)

    Strong communication and interpersonal skills

    Desirable Requirements

    Familiarity with protein or metabolite identification and profiling studies

    Background in bioinformatics/statistics

    Familiarity with basic pharmacokinetic or statistical data analyses

 
Full-Time/Part-Time Seasonal  
Location South San Francisco, CA  

This position is currently accepting applications.

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