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R&D Internship - Clinical Pharmacology & Quantitative Pharmacology 

EOE StatementWe are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status or any other characteristic protected by law.
About the Organization
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit .  

Location: Waltham, MA

We are currently seeking a Master/PhD level student with a quantitative background such as Mathematics, Statistics, Pharmacometrics, Bioinformatics, or a related field for a 10-12 week internship during the summer of 2023.


Objectives/Goals of the Position:

  •  Review bispecific and CAR-T data based on publication and approved database, and summarize what are the driving factors (e.g. drug exposure related) and impacting factors (e.g. patient characterization related) on CRS (cytokine release syndrome) and NT (neurotoxicity).
  • Based on biological mechanisms of NT and CRS, whether a general risk diagram could be proposed in linking these factors to clinical endpoints.
  • Further exposure how the learnings could be fed into the internal bispecific or CAR-T projects (e.g. QSP model development) to support dose selection.
Position Requirements


  • Quantitative background, with some experience in statistical analysis, and proficient in R programming

  • Basic understanding of PK/PD, Dose-Exposure-Response analysis, and nonlinear mixed effect modeling (NLME).

  • Basic understanding of clinical pharmacology and oncology treatment methods.

  • Minimum grade point average of 3.0



Full-Time/Part-Time Seasonal  
Location Waltham, MA  

This position is currently not accepting applications.

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