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Title

Summer Internship – Clinical Immuno-oncology research  

EOE StatementWe are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status or any other characteristic protected by law.
 
About the Organization
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit www.astrazeneca.com .  
Description

Location: Gaithersburg,MD

We are currently seeking rising undergraduate senior, master or PhD-level students working towards a degree in cell biology, immunology, or molecular biology for a 10-12 week internship during the summer of 2023. 

Objectives/Goals of the Position:

Dendritic cells (DC) play a central role in regulating adaptive immune responses and stand essential for generating potent anti-tumor CD8+ T-cell immunity via cross-presentation of tumor antigens (TA). Anti-tumoral immune responses depend on the ability of DC to recognize and endocytose apoptotic/necrotic cells, a process termed efferocytosis.

AstraZeneca’s clinical asset AZD7789 enhances human Monocyte Derived (MoDC) efferocytosis of apoptotic tumor cells and cross-presentation of TA to TA-specific CD8+ T-cells. The Student intern will utilize human tumor lines and human monocyte derived dendritic cells to further elucidate the MOA of AZD7789 in DC biology. Utilizing an established protocol and various immune-assays the intern will co-culture human MoDC with human tumor cell lines to determine what are the functional effects of AZD7789 treatment on human MoDC.

Primary Duties:

  • Lab-based 
  • Basic research
  • Human primary cell/tissue handling
  • Flow cytometry
  • Data analysis
 
Position Requirements

Position Requirements:

  • Rising undergraduate senior, master or PhD-level students working towards a degree in cell biology, immunology, or molecular biology.
  • Tissue culture and general lab techniques.
  • Minimum grade point average of 3.0+
 
Full-Time/Part-Time Seasonal  
Location Gaithersburg, MD  

This position is currently accepting applications.

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