MedImmune is the worldwide biologics research and development arm of AstraZeneca, a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of small molecule and biologic prescription medicines. MedImmune is pioneering innovative research and exploring novel pathways across key therapeutic areas, including respiratory, inflammation and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines. We are currently seeking candidates who are working towards obtaining a Bachelor's degree in Biology, Chemistry, Biochemistry, Pharmaceutical Sciences, or a relative Engineering degree. This position is for the Summer 2019 internship program in Gaithersburg, MD. Objective/Scope of the Assignment: - To evaluate if the SP Scientific LyoCapsule can be used as a scale-down model for production scale Lyophilizers Responsibilities: - Generate thermal data for multiple products on the LyoCapsule - Compare thermal data generated using the LyoCapsule with historical data at pilot-scale and production scale - Generate a scale down model on the LyoCapsule to match the thermal profiles of larger scale lyophilizers - Perform side-by-side lyophilization runs using LyoCapsule and pilot lyophilizer, comparing temperature profiles, pressure profiles, and product quality results Requirements: - Aseptic operation in a biosafety cabinet - Ability to make buffer and protein solutions - Data analysis using Microsoft Excel |