Share Email Opening
Title

Formulation Sciences Intern  

EOE StatementWe are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status or any other characteristic protected by law.
 
About the Organization
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit www.astrazeneca.com .  
Description

Intern: MedImmune Formulation Sciences

Formulation Sciences Intern

Location: Gaithersburg, MD

MedImmune is the worldwide biologics research and development arm of AstraZeneca, a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of small molecule and biologic prescription medicines. MedImmune is pioneering innovative research and exploring novel pathways across key therapeutic areas, including respiratory, inflammation and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines.

We are currently seeking candidates who are working towards obtaining a Bachelor’s Degree in Biochemistry, Chemical Engineering, Pharmaceutical Sciences, Biomedical Engineering, Chemistry or a related major for an internship during the summer of 2018. This internship opportunity is with the Formulation Sciences department.

The objective of this internship is to investigate whether oxidation and deamidation of specific residues can increase the susceptibility of the protein to aggregation/SVP formation.

Core Responsibilities:

Primary duties will be to conduct laboratory experiments. The conformational and colloidal stability of native and preferentially oxidized and deamidated mAbs will be measured using differential scanning calorimetry (DSC) and dynamic light scattering (DLS), respectively. Accelerated stability studies using elevated temperatures, agitation and/or stirring will then be used to mediate aggregation/SVP formation in the native and in the chemically modified (preferentially oxidized or deamidated) mAb formulations. Samples will be analyzed for aggregate and SVP formation using size exclusion chromatography (HPSEC) and micro-flow imaging (MFI). The intern will also be responsible for maintaining detailed experimental notes, analyzing data, and presenting findings to MedImmune scientists.

 
Position Requirements

Position Requirements:

  • General understanding of protein chemistry including degradation pathways and protein structure
  • Some laboratory experience
  • Undergraduate Freshman, Sophomore Junior, Seniors
  • Minimum GPA of 3.0+
 
Full-Time/Part-Time Seasonal  
Location Gaithersburg, MD  

This position is currently not accepting applications.

To search for an open position, please go to http://AstraZenecaPharmaceuticalsInc.appone.com



WE ALSO RECOMMEND

Other Jobs Within Same Category
-- None found --



Other Jobs Within 60 Miles
-- None found --




 


AppOne.comTM   copyrightŠ1999-2021 HR Services, Inc.
Click here for technical assistance.